Thermal, chemical and pH induced denaturation of a multimeric β-galactosidase reveals multiple unfolding pathways.

Thermal, chemical and pH induced denaturation of a multimeric β-galactosidase reveals multiple unfolding pathways.

BACKGROUND: In this case study, we analysed the properties of unfolded states and pathways leading to complete denaturation of a multimeric chick pea β-galactosidase (CpGAL), as obtained from treatment with guanidium hydrochloride, urea, elevated temperature and extreme pH. METHODOLOGY/PRINCIPAL FIN...

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Bibliographic Details
Main Authors: Devesh Kishore, Suman Kundu, Arvind M Kayastha
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3503960?pdf=render

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