Hypersensitivity of Vagal Pulmonary Afferents Induced by Tumor Necrosis Factor Alpha in Mice

Hypersensitivity of Vagal Pulmonary Afferents Induced by Tumor Necrosis Factor Alpha in Mice

Tumor necrosis factor alpha (TNFα), a pro-inflammatory cytokine, plays a significant role in the pathogenesis of allergic asthma. Inhalation of TNFα also induces airway hyperresponsiveness in healthy human subjects, and the underlying mechanism is not fully understood. A recent study reported that T...

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Bibliographic Details
Main Authors: Ruei-Lung Lin, Qihai Gu, Lu-Yuan Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Physiology
Subjects:
airway
lung
C-fiber
rapidly adapting receptor
cytokine
inflammation
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00411/full

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