Mfsd2a+ hepatocytes repopulate the liver during injury and regeneration
Hepatocytes are highly specialized cells and their fate is determined by their position in the liver as either periportal or perivenous hepatocytes. Here, Pu et al. show through genetic lineage tracing for Mfsd2 that periportal hepatocytes proliferate and reprogram into pericentral hepatocytes durin...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2016-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms13369 |
| id |
doaj-8bcbb5f141f84e2ebd07ff6d5e9adba5 |
|---|---|
| record_format |
Article |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Wenjuan Pu Hui Zhang Xiuzhen Huang Xueying Tian Lingjuan He Yue Wang Libo Zhang Qiaozhen Liu Yan Li Yi Li Huan Zhao Kuo Liu Jie Lu Yingqun Zhou Pengyu Huang Yu Nie Yan Yan Lijian Hui Kathy O. Lui Bin Zhou |
| spellingShingle |
Wenjuan Pu Hui Zhang Xiuzhen Huang Xueying Tian Lingjuan He Yue Wang Libo Zhang Qiaozhen Liu Yan Li Yi Li Huan Zhao Kuo Liu Jie Lu Yingqun Zhou Pengyu Huang Yu Nie Yan Yan Lijian Hui Kathy O. Lui Bin Zhou Mfsd2a+ hepatocytes repopulate the liver during injury and regeneration Nature Communications |
| author_facet |
Wenjuan Pu Hui Zhang Xiuzhen Huang Xueying Tian Lingjuan He Yue Wang Libo Zhang Qiaozhen Liu Yan Li Yi Li Huan Zhao Kuo Liu Jie Lu Yingqun Zhou Pengyu Huang Yu Nie Yan Yan Lijian Hui Kathy O. Lui Bin Zhou |
| author_sort |
Wenjuan Pu |
| title |
Mfsd2a+ hepatocytes repopulate the liver during injury and regeneration |
| title_short |
Mfsd2a+ hepatocytes repopulate the liver during injury and regeneration |
| title_full |
Mfsd2a+ hepatocytes repopulate the liver during injury and regeneration |
| title_fullStr |
Mfsd2a+ hepatocytes repopulate the liver during injury and regeneration |
| title_full_unstemmed |
Mfsd2a+ hepatocytes repopulate the liver during injury and regeneration |
| title_sort |
mfsd2a+ hepatocytes repopulate the liver during injury and regeneration |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2016-11-01 |
| description |
Hepatocytes are highly specialized cells and their fate is determined by their position in the liver as either periportal or perivenous hepatocytes. Here, Pu et al. show through genetic lineage tracing for Mfsd2 that periportal hepatocytes proliferate and reprogram into pericentral hepatocytes during liver regeneration and injury. |
| url |
https://doi.org/10.1038/ncomms13369 |
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doaj-8bcbb5f141f84e2ebd07ff6d5e9adba52021-05-11T10:41:37ZengNature Publishing GroupNature Communications2041-17232016-11-017111510.1038/ncomms13369Mfsd2a+ hepatocytes repopulate the liver during injury and regenerationWenjuan Pu0Hui Zhang1Xiuzhen Huang2Xueying Tian3Lingjuan He4Yue Wang5Libo Zhang6Qiaozhen Liu7Yan Li8Yi Li9Huan Zhao10Kuo Liu11Jie Lu12Yingqun Zhou13Pengyu Huang14Yu Nie15Yan Yan16Lijian Hui17Kathy O. Lui18Bin Zhou19Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of SciencesKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of SciencesKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of SciencesKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of SciencesKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of SciencesKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of SciencesKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of SciencesKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of SciencesKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of SciencesKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of SciencesKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of SciencesKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of SciencesDepartment of Gastroenterology, Shanghai 10th People’s Hospital, Tongji University School of MedicineDepartment of Gastroenterology, Shanghai 10th People’s Hospital, Tongji University School of MedicineSchool of Life Science and Technology, Shanghai Tech UniversityState Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Cardiology, Zhongshan Hospital, Fudan UniversityState Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academic of SciencesDepartment of Chemical Pathology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales HospitalKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of SciencesHepatocytes are highly specialized cells and their fate is determined by their position in the liver as either periportal or perivenous hepatocytes. Here, Pu et al. show through genetic lineage tracing for Mfsd2 that periportal hepatocytes proliferate and reprogram into pericentral hepatocytes during liver regeneration and injury.https://doi.org/10.1038/ncomms13369 |