Investigation the effect of Commiphora mukul on blood glucose and Serum lipid profile in diabetic rats

• Main Authors: leila Shirazi, Iraj Salehi, Shirin Moradkhani
• Format: Article
• Language: fas
• Published: Yasuj University Of Medical Sciences 2015-01-01
• Series: Armaghane Danesh Bimonthly Journal
• Subjects: Diabetes; Commiphora mukul; glucose; lipid profile
• Online Access: http://armaghanj.yums.ac.ir/browse.php?a_code=A-10-1-6&slc_lang=en&sid=1
• ISSN: 1728-6506; 1728-6514

Background & aim: The decrease of serum glucose level and lipids in diabetic patients is clinically significant. The purpose of this study was to determine the effect of Commiphora mukul extract on blood sugar and lipid profile in diabetic rats. Methods: In the present experimental study, thirty-two male Wistar rats were randomly divided into four groups: control, control treated with the extract, diabetic and diabetic treated with the extract. Diabetes was induced by intraperitoneal injection of Streptozotocin. In an eight week period, the control group of normal saline and the control group and diabetic recipient extract of CM oleo gum blue resin was given by gavage. Treatment resumed eight weeks with onset of hyperglycemia. The control and diabetic control groups received normal saline orally. Extract treated control and extract treated diabetic groups received extract of Commiphora mukul gum (300 mg/kg P.O.) daily by gavage. At the end of this period, blood samples were collected from each rat and biochemical tests for investigation of glucose level and lipid profile was performed. One- way analysis of variance (ANOVA) statistical test and Post-hoc test Tukey’s were used for data analysis Results: The study indicated that diabetes increases the serum levels of glucose, cholesterol, triglycerides, LDL and HDL. Administration of Commiphora mukul gum extract in diabetic groups significantly decreased the serum level of glucose, cholesterol(p<0.01) and triglyceride and LDL(p<0.001) and increased HDL(p<0.01). Conclusion: Commiphora mukul gum extract may well improve undesirable effects of diabetes on serum level of glucose, cholesterol, triglyceride, LDL and HDL.