Effects of a Single Escape Mutation on T Cell and HIV-1 Co-adaptation

Effects of a Single Escape Mutation on T Cell and HIV-1 Co-adaptation

The mechanistic basis for the progressive accumulation of Y135F Nef mutant viruses in the HIV-1-infected population remains poorly understood. Y135F viruses carry the 2F mutation within RW8 and RF10, which are two HLA-A∗24:02-restricted superimposed Nef epitopes recognized by distinct and adaptable...

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Main Authors:	Xiaoming Sun, Yi Shi, Tomohiro Akahoshi, Mamoru Fujiwara, Hiroyuki Gatanaga, Christian Schönbach, Nozomi Kuse, Victor Appay, George F. Gao, Shinichi Oka, Masafumi Takiguchi
Format:	Article
Language:	English
Published:	Elsevier 2016-06-01
Series:	Cell Reports
Online Access:	http://www.sciencedirect.com/science/article/pii/S221112471630585X

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