A practical and efficient approach to imidazo[1,2-a]pyridine-fused isoquinolines through the post-GBB transformation strategy

Diversity-oriented synthesis of the biologically intriguing imidazo[1,2-a]pyridine-fused isoquinoline systems from readily available starting materials was achieved through the Groebke–Blackburn–Bienaymé reaction followed by a gold-catalyzed cyclization strategy. The synthetic approach is characteri...

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Main Authors:	Taofeng Shao, Zhiming Gong, Tianyi Su, Wei Hao, Chao Che
Format:	Article
Language:	English
Published:	Beilstein-Institut 2017-05-01
Series:	Beilstein Journal of Organic Chemistry
Subjects:	Groebke–Blackburn–Bienaymé reaction imidazo[1,2-a]pyridines isoquinolines multicomponent reaction Ugi reaction
Online Access:	https://doi.org/10.3762/bjoc.13.82

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spelling	doaj-8bc86030b61e4b6dab017ce45b72637e2021-02-02T01:36:06ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972017-05-0113181782410.3762/bjoc.13.821860-5397-13-82A practical and efficient approach to imidazo[1,2-a]pyridine-fused isoquinolines through the post-GBB transformation strategyTaofeng Shao0Zhiming Gong1Tianyi Su2Wei Hao3Chao Che4Laboratory of Chemical Genomics, Engineering Laboratory for Chiral Drug Synthesis, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, ChinaLaboratory of Chemical Genomics, Engineering Laboratory for Chiral Drug Synthesis, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, ChinaLaboratory of Chemical Genomics, Engineering Laboratory for Chiral Drug Synthesis, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, ChinaLaboratory of Chemical Genomics, Engineering Laboratory for Chiral Drug Synthesis, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, ChinaLaboratory of Chemical Genomics, Engineering Laboratory for Chiral Drug Synthesis, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, ChinaDiversity-oriented synthesis of the biologically intriguing imidazo[1,2-a]pyridine-fused isoquinoline systems from readily available starting materials was achieved through the Groebke–Blackburn–Bienaymé reaction followed by a gold-catalyzed cyclization strategy. The synthetic approach is characterized by mild reaction conditions and a broad substrate scope, allowing for the rapid construction of structurally complex and diverse heterocycles in moderate to good yields.https://doi.org/10.3762/bjoc.13.82Groebke–Blackburn–Bienaymé reactionimidazo[1,2-a]pyridinesisoquinolinesmulticomponent reactionUgi reaction
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Taofeng Shao Zhiming Gong Tianyi Su Wei Hao Chao Che
spellingShingle	Taofeng Shao Zhiming Gong Tianyi Su Wei Hao Chao Che A practical and efficient approach to imidazo[1,2-a]pyridine-fused isoquinolines through the post-GBB transformation strategy Beilstein Journal of Organic Chemistry Groebke–Blackburn–Bienaymé reaction imidazo[1,2-a]pyridines isoquinolines multicomponent reaction Ugi reaction
author_facet	Taofeng Shao Zhiming Gong Tianyi Su Wei Hao Chao Che
author_sort	Taofeng Shao
title	A practical and efficient approach to imidazo[1,2-a]pyridine-fused isoquinolines through the post-GBB transformation strategy
title_short	A practical and efficient approach to imidazo[1,2-a]pyridine-fused isoquinolines through the post-GBB transformation strategy
title_full	A practical and efficient approach to imidazo[1,2-a]pyridine-fused isoquinolines through the post-GBB transformation strategy
title_fullStr	A practical and efficient approach to imidazo[1,2-a]pyridine-fused isoquinolines through the post-GBB transformation strategy
title_full_unstemmed	A practical and efficient approach to imidazo[1,2-a]pyridine-fused isoquinolines through the post-GBB transformation strategy
title_sort	practical and efficient approach to imidazo[1,2-a]pyridine-fused isoquinolines through the post-gbb transformation strategy
publisher	Beilstein-Institut
series	Beilstein Journal of Organic Chemistry
issn	1860-5397
publishDate	2017-05-01
description	Diversity-oriented synthesis of the biologically intriguing imidazo[1,2-a]pyridine-fused isoquinoline systems from readily available starting materials was achieved through the Groebke–Blackburn–Bienaymé reaction followed by a gold-catalyzed cyclization strategy. The synthetic approach is characterized by mild reaction conditions and a broad substrate scope, allowing for the rapid construction of structurally complex and diverse heterocycles in moderate to good yields.
topic	Groebke–Blackburn–Bienaymé reaction imidazo[1,2-a]pyridines isoquinolines multicomponent reaction Ugi reaction
url	https://doi.org/10.3762/bjoc.13.82
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A practical and efficient approach to imidazo[1,2-a]pyridine-fused isoquinolines through the post-GBB transformation strategy

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