Androgens impair β-cell function in a mouse model of polycystic ovary syndrome by activating endoplasmic reticulum stress

Androgens impair β-cell function in a mouse model of polycystic ovary syndrome by activating endoplasmic reticulum stress

Background: Androgens excess results in endoplasmic reticulum (ER) stress, which is an important cause of β cells dysfunction. Here, we investigated the molecular regulation of androgens excess, ER stress, and β-cell function in polycystic ovary syndrome (PCOS). Methods: PCOS mouse model was estab...

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Bibliographic Details
Main Authors: Bo Zhu, Yumei Chen, Fang Xu, Xiaolu Shen, Xuanyu Chen, Jieqiang Lv, Songying Zhang
Format: Article
Language:English
Published: Bioscientifica 2021-04-01
Series:Endocrine Connections
Subjects:
er stress
androgens excess
β cells
hyperinsulinemia
pcos
Online Access:https://ec.bioscientifica.com/view/journals/ec/10/3/EC-20-0608.xml

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https://ec.bioscientifica.com/view/journals/ec/10/3/EC-20-0608.xml

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