Design of multi-scale protein complexes by hierarchical building block fusion
De novo design of self-assembling protein nanostructures and materials is of significant interest, however design of complex, multi-component assemblies is challenging. Here, the authors present a stepwise hierarchical approach to build such assemblies using helical repeat and helical bundle protein...
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Nature Publishing Group
2021-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-22276-z |
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doaj-8bb80e33cedb4e58856a97a798a217fd2021-04-18T11:14:02ZengNature Publishing GroupNature Communications2041-17232021-04-0112111010.1038/s41467-021-22276-zDesign of multi-scale protein complexes by hierarchical building block fusionYang Hsia0Rubul Mout1William Sheffler2Natasha I. Edman3Ivan Vulovic4Young-Jun Park5Rachel L. Redler6Matthew J. Bick7Asim K. Bera8Alexis Courbet9Alex Kang10T. J. Brunette11Una Nattermann12Evelyn Tsai13Ayesha Saleem14Cameron M. Chow15Damian Ekiert16Gira Bhabha17David Veesler18David Baker19Department of Biochemistry, University of WashingtonDepartment of Biochemistry, University of WashingtonDepartment of Biochemistry, University of WashingtonDepartment of Biochemistry, University of WashingtonDepartment of Biochemistry, University of WashingtonDepartment of Biochemistry, University of WashingtonDepartment of Cell Biology and Skirball Institute of Biomolecular Medicine, New York University School of MedicineDepartment of Biochemistry, University of WashingtonDepartment of Biochemistry, University of WashingtonDepartment of Biochemistry, University of WashingtonDepartment of Biochemistry, University of WashingtonDepartment of Biochemistry, University of WashingtonDepartment of Biochemistry, University of WashingtonDepartment of Biochemistry, University of WashingtonDepartment of Biochemistry, University of WashingtonDepartment of Biochemistry, University of WashingtonDepartment of Cell Biology and Skirball Institute of Biomolecular Medicine, New York University School of MedicineDepartment of Cell Biology and Skirball Institute of Biomolecular Medicine, New York University School of MedicineDepartment of Biochemistry, University of WashingtonDepartment of Biochemistry, University of WashingtonDe novo design of self-assembling protein nanostructures and materials is of significant interest, however design of complex, multi-component assemblies is challenging. Here, the authors present a stepwise hierarchical approach to build such assemblies using helical repeat and helical bundle proteins as building blocks, and provide an in-depth structural characterization of the resulting assemblies.https://doi.org/10.1038/s41467-021-22276-z |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Yang Hsia Rubul Mout William Sheffler Natasha I. Edman Ivan Vulovic Young-Jun Park Rachel L. Redler Matthew J. Bick Asim K. Bera Alexis Courbet Alex Kang T. J. Brunette Una Nattermann Evelyn Tsai Ayesha Saleem Cameron M. Chow Damian Ekiert Gira Bhabha David Veesler David Baker |
| spellingShingle |
Yang Hsia Rubul Mout William Sheffler Natasha I. Edman Ivan Vulovic Young-Jun Park Rachel L. Redler Matthew J. Bick Asim K. Bera Alexis Courbet Alex Kang T. J. Brunette Una Nattermann Evelyn Tsai Ayesha Saleem Cameron M. Chow Damian Ekiert Gira Bhabha David Veesler David Baker Design of multi-scale protein complexes by hierarchical building block fusion Nature Communications |
| author_facet |
Yang Hsia Rubul Mout William Sheffler Natasha I. Edman Ivan Vulovic Young-Jun Park Rachel L. Redler Matthew J. Bick Asim K. Bera Alexis Courbet Alex Kang T. J. Brunette Una Nattermann Evelyn Tsai Ayesha Saleem Cameron M. Chow Damian Ekiert Gira Bhabha David Veesler David Baker |
| author_sort |
Yang Hsia |
| title |
Design of multi-scale protein complexes by hierarchical building block fusion |
| title_short |
Design of multi-scale protein complexes by hierarchical building block fusion |
| title_full |
Design of multi-scale protein complexes by hierarchical building block fusion |
| title_fullStr |
Design of multi-scale protein complexes by hierarchical building block fusion |
| title_full_unstemmed |
Design of multi-scale protein complexes by hierarchical building block fusion |
| title_sort |
design of multi-scale protein complexes by hierarchical building block fusion |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-04-01 |
| description |
De novo design of self-assembling protein nanostructures and materials is of significant interest, however design of complex, multi-component assemblies is challenging. Here, the authors present a stepwise hierarchical approach to build such assemblies using helical repeat and helical bundle proteins as building blocks, and provide an in-depth structural characterization of the resulting assemblies. |
| url |
https://doi.org/10.1038/s41467-021-22276-z |
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