The Role of Oxidative Stress, Mitochondrial Function, and Autophagy in Diabetic Polyneuropathy

Diabetic polyneuropathy (DPN) is the most frequent and prevalent chronic complication of diabetes mellitus (DM). The state of persistent hyperglycemia leads to an increase in the production of cytosolic and mitochondrial reactive oxygen species (ROS) and favors deregulation of the antioxidant defens...

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Bibliographic Details
Main Authors: Sonia Sifuentes-Franco, Fermín Paul Pacheco-Moisés, Adolfo Daniel Rodríguez-Carrizalez, Alejandra Guillermina Miranda-Díaz
Format: Article
Language:English
Published: Hindawi Limited 2017-01-01
Series:Journal of Diabetes Research
Online Access:http://dx.doi.org/10.1155/2017/1673081