Notoginsenoside Ft1 acts as a TGR5 agonist but FXR antagonist to alleviate high fat diet-induced obesity and insulin resistance in mice

Notoginsenoside Ft1 acts as a TGR5 agonist but FXR antagonist to alleviate high fat diet-induced obesity and insulin resistance in mice

Obesity and its associated complications are highly related to a current public health crisis around the world. A growing body of evidence has indicated that G-protein coupled bile acid (BA) receptor TGR5 (also known as Gpbar-1) is a potential drug target to treat obesity and associated metabolic di...

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Bibliographic Details
Main Authors: Lili Ding, Qiaoling Yang, Eryun Zhang, Yangmeng Wang, Siming Sun, Yingbo Yang, Tong Tian, Zhengcai Ju, Linshan Jiang, Xunjiang Wang, Zhengtao Wang, Wendong Huang, Li Yang
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Notoginsenoside Ft1
Obesity
Insulin resistance
Bile acids
TGR5
FXR
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383521001106

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