BV-2 Microglial Cells Respond to Rotenone Toxic Insult by Modifying Pregnenolone, 5α-Dihydroprogesterone and Pregnanolone Levels

BV-2 Microglial Cells Respond to Rotenone Toxic Insult by Modifying Pregnenolone, 5α-Dihydroprogesterone and Pregnanolone Levels

Neuroinflammation, whose distinctive sign is the activation of microglia, is supposed to play a key role in the development and progression of neurodegenerative diseases. The aim of this investigation was to determine levels of neurosteroids produced by resting and injured BV-2 microglial cells. BV-...

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Bibliographic Details
Main Authors: Rossella Avallone, Chiara Lucchi, Giulia Puja, Alessandro Codeluppi, Monica Filaferro, Giovanni Vitale, Cecilia Rustichelli, Giuseppe Biagini
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cells
Subjects:
steroidogenesis
microglia
BV-2 cells
neurosteroids
rotenone
ROS
Online Access:https://www.mdpi.com/2073-4409/9/9/2091

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