The NTP generating activity of pyruvate kinase II is critical for apicoplast maintenance in Plasmodium falciparum

The NTP generating activity of pyruvate kinase II is critical for apicoplast maintenance in Plasmodium falciparum

The apicoplast of Plasmodium falciparum parasites is believed to rely on the import of three-carbon phosphate compounds for use in organelle anabolic pathways, in addition to the generation of energy and reducing power within the organelle. We generated a series of genetic deletions in an apicoplast...

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Bibliographic Details
Main Authors: Russell P Swift, Krithika Rajaram, Cyrianne Keutcha, Hans B Liu, Bobby Kwan, Amanda Dziedzic, Anne E Jedlicka, Sean T Prigge
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-08-01
Series:eLife
Subjects:
apicoplast
malaria
Pyruvate Kinase
plasmodium
microarray
carbon metabolism
Online Access:https://elifesciences.org/articles/50807

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