Ultrasound-guided percutaneous cinobufagin injection for treatment of portal vein tumor thrombus in primary liver cancer patients

• Main Author: JI Jianfeng
• Format: Article
• Language: zho
• Published: Editorial Department of Journal of Clinical Hepatology 2015-06-01
• Series: Linchuang Gandanbing Zazhi
• Subjects: liver neoplasms; portal vein tumor thrombosis; ultrasonography; interventional; cinobufagin
• Online Access: http://www.lcgdbzz.org/qk_content.asp?id=6609&ClassID=58143850
• ISSN: 1001-5256; 1001-5256

ObjectiveTo evaluate the clinical value of ultrasound-guided percutaneous cinobufagin injection for the treatment of portal vein tumor thrombus (PVTT) in primary liver cancer (PLC) patients. MethodsA total of 25 PLC patients with PVTT who were admitted to our hospital from January 2009 to March 2012 were recruited in this study. These patients underwent ultrasound-guided percutaneous cinobufagin injection three times a week, and each course of treatment was 4-5 weeks. After treatment, the clinical efficacy and survival rates were determined, and the changes in levels of alpha fetoprotein (AFP) and alanine aminotransferase (ALT) were evaluated. Results Seventeen patients showed varying degrees of improvement after treatment, with an overall response rate of 68%. In addition, the levels of AFP and ALT were significantly reduced after treatment (P＜0.05). The survival rates at 3, 6, 12, and 24 months after treatment were 88%, 76%, 60%, and 32%, respectively. ConclusionUltrasound-guided percutaneous cinobufagin injection has good efficacy in the treatment of PVTT in PLC patients and shows a good clinical value.