Onsite GTP fuelling via DYNAMO1 drives division of mitochondria and peroxisomes

Onsite GTP fuelling via DYNAMO1 drives division of mitochondria and peroxisomes

Mitochondria and peroxisomes require a dynamin-like GTPase to remodel membranes during division. Here the authors identify DYNAMO1, a nucleoside diphosphate kinase-like protein that generates a local source of GTP to promote constriction of the division machinery and produce daughter organelles.

Bibliographic Details
Main Authors: Yuuta Imoto, Yuichi Abe, Masanori Honsho, Kanji Okumoto, Mio Ohnuma, Haruko Kuroiwa, Tsuneyoshi Kuroiwa, Yukio Fujiki
Format: Article
Language:English
Published: Nature Publishing Group 2018-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07009-z
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spelling doaj-8b93f747c802479797d6e341c8b1981c2021-05-11T10:22:26ZengNature Publishing GroupNature Communications2041-17232018-11-019111210.1038/s41467-018-07009-zOnsite GTP fuelling via DYNAMO1 drives division of mitochondria and peroxisomesYuuta Imoto0Yuichi Abe1Masanori Honsho2Kanji Okumoto3Mio Ohnuma4Haruko Kuroiwa5Tsuneyoshi Kuroiwa6Yukio Fujiki7Division of Organelle Homeostasis, Medical Institute of Bioregulation, Kyushu UniversityDivision of Organelle Homeostasis, Medical Institute of Bioregulation, Kyushu UniversityDivision of Organelle Homeostasis, Medical Institute of Bioregulation, Kyushu UniversityDepartment of Biology, Faculty of Sciences, Kyushu UniversityInstitute of Technology, Hiroshima CollegeDepartment of Chemical and Biological Science, Faculty of Science, Japan Women’s UniversityDepartment of Chemical and Biological Science, Faculty of Science, Japan Women’s UniversityDivision of Organelle Homeostasis, Medical Institute of Bioregulation, Kyushu UniversityMitochondria and peroxisomes require a dynamin-like GTPase to remodel membranes during division. Here the authors identify DYNAMO1, a nucleoside diphosphate kinase-like protein that generates a local source of GTP to promote constriction of the division machinery and produce daughter organelles.https://doi.org/10.1038/s41467-018-07009-z
collection DOAJ
language English
format Article
sources DOAJ
author Yuuta Imoto
Yuichi Abe
Masanori Honsho
Kanji Okumoto
Mio Ohnuma
Haruko Kuroiwa
Tsuneyoshi Kuroiwa
Yukio Fujiki
spellingShingle Yuuta Imoto
Yuichi Abe
Masanori Honsho
Kanji Okumoto
Mio Ohnuma
Haruko Kuroiwa
Tsuneyoshi Kuroiwa
Yukio Fujiki
Onsite GTP fuelling via DYNAMO1 drives division of mitochondria and peroxisomes
Nature Communications
author_facet Yuuta Imoto
Yuichi Abe
Masanori Honsho
Kanji Okumoto
Mio Ohnuma
Haruko Kuroiwa
Tsuneyoshi Kuroiwa
Yukio Fujiki
author_sort Yuuta Imoto
title Onsite GTP fuelling via DYNAMO1 drives division of mitochondria and peroxisomes
title_short Onsite GTP fuelling via DYNAMO1 drives division of mitochondria and peroxisomes
title_full Onsite GTP fuelling via DYNAMO1 drives division of mitochondria and peroxisomes
title_fullStr Onsite GTP fuelling via DYNAMO1 drives division of mitochondria and peroxisomes
title_full_unstemmed Onsite GTP fuelling via DYNAMO1 drives division of mitochondria and peroxisomes
title_sort onsite gtp fuelling via dynamo1 drives division of mitochondria and peroxisomes
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-11-01
description Mitochondria and peroxisomes require a dynamin-like GTPase to remodel membranes during division. Here the authors identify DYNAMO1, a nucleoside diphosphate kinase-like protein that generates a local source of GTP to promote constriction of the division machinery and produce daughter organelles.
url https://doi.org/10.1038/s41467-018-07009-z
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