Re-Designed Recombinant Hepatitis B Virus Vectors Enable Efficient Delivery of Versatile Cargo Genes to Hepatocytes with Improved Safety

Re-Designed Recombinant Hepatitis B Virus Vectors Enable Efficient Delivery of Versatile Cargo Genes to Hepatocytes with Improved Safety

Hepatitis B virus (HBV) takes humans as its sole natural host, and productive infection in vivo is restricted exclusively to hepatocytes in the liver. Consequently, HBV-derived viral vectors are attractive candidates for liver-targeting gene therapies. Previously, we developed a novel recombinant HB...

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Bibliographic Details
Main Authors: Weiya Bai, Xiaoxian Cui, Ruidong Chen, Shuai Tao, Ran Hong, Jiming Zhang, Junqi Zhang, Yongxiang Wang, Youhua Xie, Jing Liu
Format: Article
Language:English
Published: MDPI AG 2016-05-01
Series:Viruses
Subjects:
HBV
gene therapy
viral vector
hepatocyte
Online Access:http://www.mdpi.com/1999-4915/8/5/129

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