Comparative analysis of Mycobacterium tuberculosis pe and ppe genes reveals high sequence variation and an apparent absence of selective constraints.

Comparative analysis of Mycobacterium tuberculosis pe and ppe genes reveals high sequence variation and an apparent absence of selective constraints.

Mycobacterium tuberculosis complex (MTBC) genomes contain 2 large gene families termed pe and ppe. The function of pe/ppe proteins remains enigmatic but studies suggest that they are secreted or cell surface associated and are involved in bacterial virulence. Previous studies have also shown that so...

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Bibliographic Details
Main Authors: Christopher R E McEvoy, Ruben Cloete, Borna Müller, Anita C Schürch, Paul D van Helden, Sebastien Gagneux, Robin M Warren, Nicolaas C Gey van Pittius
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3319526?pdf=render

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http://europepmc.org/articles/PMC3319526?pdf=render

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