Targeting myelin lipid metabolism as a potential therapeutic strategy in a model of CMT1A neuropathy
Charcot–Marie–Tooth disease 1A (CMT1A) is a peripheral demyelinating disease. Here, the authors demonstrate in a rodent model of CMT1A that Schwann cells have impairments in lipid biosynthesis, and that restoring lipids via diet can reverse the dysmyelinating phenotype in these animals.
Bibliographic Details
| Main Authors: |
R. Fledrich,
T. Abdelaal,
L. Rasch,
V. Bansal,
V. Schütza,
B. Brügger,
C. Lüchtenborg,
T. Prukop,
J. Stenzel,
R. U. Rahman,
D. Hermes,
D. Ewers,
W. Möbius,
T. Ruhwedel,
I. Katona,
J. Weis,
D. Klein,
R. Martini,
W. Brück,
W. C. Müller,
S. Bonn,
I. Bechmann,
K. A. Nave,
R. M. Stassart,
M. W. Sereda |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2018-08-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-018-05420-0
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