Spontaneous Regression of Hepatocellular Carcinoma and Review of Reports in the Published English Literature

Background. Spontaneous regression of hepatocellular carcinoma (HCC) is a rare event, although it has been described by numerous groups. The long-term fate of individuals experiencing an SR is not well described, and the underlying mechanism(s) of SR are unknown. Case Presentation: A 79-year-old Asi...

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Main Authors:	Moaz B. Y. Chohan, Nick Taylor, Carla Coffin, Kelly W. Burak, Oliver F. Bathe
Format:	Article
Language:	English
Published:	Hindawi Limited 2019-01-01
Series:	Case Reports in Medicine
Online Access:	http://dx.doi.org/10.1155/2019/9756758

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spelling	doaj-8b8cf9fb7f864f34a5a2f1ba088a92f52020-11-24T23:05:14ZengHindawi LimitedCase Reports in Medicine1687-96271687-96352019-01-01201910.1155/2019/97567589756758Spontaneous Regression of Hepatocellular Carcinoma and Review of Reports in the Published English LiteratureMoaz B. Y. Chohan0Nick Taylor1Carla Coffin2Kelly W. Burak3Oliver F. Bathe4Departments of Surgery, University of Calgary, Calgary, AB, CanadaDepartments of Surgery, University of Calgary, Calgary, AB, CanadaDepartments of Medicine, University of Calgary, Calgary, AB, CanadaDepartments of Medicine, University of Calgary, Calgary, AB, CanadaDepartments of Surgery, University of Calgary, Calgary, AB, CanadaBackground. Spontaneous regression of hepatocellular carcinoma (HCC) is a rare event, although it has been described by numerous groups. The long-term fate of individuals experiencing an SR is not well described, and the underlying mechanism(s) of SR are unknown. Case Presentation: A 79-year-old Asian female with metastatic HCC taking only valsartan for hypertension had a marked reduction in tumor dimension in the primary tumor and the pulmonary metastases. Serum alpha-fetoprotein (AFP) decreased from 17,833 μg/L to 26 μg/L. Her disease progressed after 71 months, and she died shortly after. In a review of 66 patients with SR reported in the English literature, median survival was 83 months. Median survival in 37 cases that underwent resection after SR was 108 months. Conclusions. The case and a review of the literature illustrate that SR is often durable and associated with an excellent prognosis. Understanding the underlying mechanism of SR may point to novel therapeutic strategies.http://dx.doi.org/10.1155/2019/9756758
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Moaz B. Y. Chohan Nick Taylor Carla Coffin Kelly W. Burak Oliver F. Bathe
spellingShingle	Moaz B. Y. Chohan Nick Taylor Carla Coffin Kelly W. Burak Oliver F. Bathe Spontaneous Regression of Hepatocellular Carcinoma and Review of Reports in the Published English Literature Case Reports in Medicine
author_facet	Moaz B. Y. Chohan Nick Taylor Carla Coffin Kelly W. Burak Oliver F. Bathe
author_sort	Moaz B. Y. Chohan
title	Spontaneous Regression of Hepatocellular Carcinoma and Review of Reports in the Published English Literature
title_short	Spontaneous Regression of Hepatocellular Carcinoma and Review of Reports in the Published English Literature
title_full	Spontaneous Regression of Hepatocellular Carcinoma and Review of Reports in the Published English Literature
title_fullStr	Spontaneous Regression of Hepatocellular Carcinoma and Review of Reports in the Published English Literature
title_full_unstemmed	Spontaneous Regression of Hepatocellular Carcinoma and Review of Reports in the Published English Literature
title_sort	spontaneous regression of hepatocellular carcinoma and review of reports in the published english literature
publisher	Hindawi Limited
series	Case Reports in Medicine
issn	1687-9627 1687-9635
publishDate	2019-01-01
description	Background. Spontaneous regression of hepatocellular carcinoma (HCC) is a rare event, although it has been described by numerous groups. The long-term fate of individuals experiencing an SR is not well described, and the underlying mechanism(s) of SR are unknown. Case Presentation: A 79-year-old Asian female with metastatic HCC taking only valsartan for hypertension had a marked reduction in tumor dimension in the primary tumor and the pulmonary metastases. Serum alpha-fetoprotein (AFP) decreased from 17,833 μg/L to 26 μg/L. Her disease progressed after 71 months, and she died shortly after. In a review of 66 patients with SR reported in the English literature, median survival was 83 months. Median survival in 37 cases that underwent resection after SR was 108 months. Conclusions. The case and a review of the literature illustrate that SR is often durable and associated with an excellent prognosis. Understanding the underlying mechanism of SR may point to novel therapeutic strategies.
url	http://dx.doi.org/10.1155/2019/9756758
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Spontaneous Regression of Hepatocellular Carcinoma and Review of Reports in the Published English Literature

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