Epidemiology of hepatitis C virus infection in highly endemic HBV areas in China.

BACKGROUND: Wuwei City has the highest prevalence of hepatitis B virus (HBV) in China. From 2007 to 2011, the average reported incidence rate of hepatitis B was 634.56/100,000 people. However, studies assessing the epidemic features and risk factors of HCV in the general population of Wuwei City are...

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Main Authors: Duan Li, Yong Long, Tingcai Wang, Dan Xiao, Jingxia Zhang, Zhiwen Guo, Bo Wang, Yongping Yan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3555996?pdf=render
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spelling doaj-8b8c5a342d334bf38e402e7d9210f1b02020-11-25T01:48:09ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0181e5481510.1371/journal.pone.0054815Epidemiology of hepatitis C virus infection in highly endemic HBV areas in China.Duan LiYong LongTingcai WangDan XiaoJingxia ZhangZhiwen GuoBo WangYongping YanBACKGROUND: Wuwei City has the highest prevalence of hepatitis B virus (HBV) in China. From 2007 to 2011, the average reported incidence rate of hepatitis B was 634.56/100,000 people. However, studies assessing the epidemic features and risk factors of HCV in the general population of Wuwei City are limited. METHODS: A total of 7189 people were interviewed and screened for HCV antibodies. HCV RNA and HCV genotypes were analyzed by PCR. Relevant information was obtained from the general population using a standardized questionnaire, and association and logistic regression analyses were conducted. RESULTS: The anti-HCV prevalence was 1.64% (118/7189), and HCV-RNA was detected in 37.29% (44/118) of the anti-HCV positive samples. The current HCV infection rate was 0.61% (44/7189) in the Wuwei general population. Hepatitis C infection rate was generally higher in the plains regions (χ(2) = 27.54,P<0.05), and the most predominant HCV genotypes were 2a (59.1%) and 1b (34.1%). The concurrent HCV and HBV infection rate was 1.37%, and a history of blood transfusion (OR = 17.9, 95% CI: 6.1 to 52.6, p<0.001) was an independent risk factor for HCV positivity. CONCLUSIONS: Although Wuwei is a highly endemic area for HBV, the anti-HCV positive rate in the general population is low. More than one-third of HCV-infected people were unaware of their infection; this may become an important risk factor for hepatitis C prevalence in the general population. Maintaining blood safety is important in order to help reduce the burden of HCV infection in developing regions of China.http://europepmc.org/articles/PMC3555996?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Duan Li
Yong Long
Tingcai Wang
Dan Xiao
Jingxia Zhang
Zhiwen Guo
Bo Wang
Yongping Yan
spellingShingle Duan Li
Yong Long
Tingcai Wang
Dan Xiao
Jingxia Zhang
Zhiwen Guo
Bo Wang
Yongping Yan
Epidemiology of hepatitis C virus infection in highly endemic HBV areas in China.
PLoS ONE
author_facet Duan Li
Yong Long
Tingcai Wang
Dan Xiao
Jingxia Zhang
Zhiwen Guo
Bo Wang
Yongping Yan
author_sort Duan Li
title Epidemiology of hepatitis C virus infection in highly endemic HBV areas in China.
title_short Epidemiology of hepatitis C virus infection in highly endemic HBV areas in China.
title_full Epidemiology of hepatitis C virus infection in highly endemic HBV areas in China.
title_fullStr Epidemiology of hepatitis C virus infection in highly endemic HBV areas in China.
title_full_unstemmed Epidemiology of hepatitis C virus infection in highly endemic HBV areas in China.
title_sort epidemiology of hepatitis c virus infection in highly endemic hbv areas in china.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2013-01-01
description BACKGROUND: Wuwei City has the highest prevalence of hepatitis B virus (HBV) in China. From 2007 to 2011, the average reported incidence rate of hepatitis B was 634.56/100,000 people. However, studies assessing the epidemic features and risk factors of HCV in the general population of Wuwei City are limited. METHODS: A total of 7189 people were interviewed and screened for HCV antibodies. HCV RNA and HCV genotypes were analyzed by PCR. Relevant information was obtained from the general population using a standardized questionnaire, and association and logistic regression analyses were conducted. RESULTS: The anti-HCV prevalence was 1.64% (118/7189), and HCV-RNA was detected in 37.29% (44/118) of the anti-HCV positive samples. The current HCV infection rate was 0.61% (44/7189) in the Wuwei general population. Hepatitis C infection rate was generally higher in the plains regions (χ(2) = 27.54,P<0.05), and the most predominant HCV genotypes were 2a (59.1%) and 1b (34.1%). The concurrent HCV and HBV infection rate was 1.37%, and a history of blood transfusion (OR = 17.9, 95% CI: 6.1 to 52.6, p<0.001) was an independent risk factor for HCV positivity. CONCLUSIONS: Although Wuwei is a highly endemic area for HBV, the anti-HCV positive rate in the general population is low. More than one-third of HCV-infected people were unaware of their infection; this may become an important risk factor for hepatitis C prevalence in the general population. Maintaining blood safety is important in order to help reduce the burden of HCV infection in developing regions of China.
url http://europepmc.org/articles/PMC3555996?pdf=render
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