Epidemiology of hepatitis C virus infection in highly endemic HBV areas in China.
BACKGROUND: Wuwei City has the highest prevalence of hepatitis B virus (HBV) in China. From 2007 to 2011, the average reported incidence rate of hepatitis B was 634.56/100,000 people. However, studies assessing the epidemic features and risk factors of HCV in the general population of Wuwei City are...
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doaj-8b8c5a342d334bf38e402e7d9210f1b02020-11-25T01:48:09ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0181e5481510.1371/journal.pone.0054815Epidemiology of hepatitis C virus infection in highly endemic HBV areas in China.Duan LiYong LongTingcai WangDan XiaoJingxia ZhangZhiwen GuoBo WangYongping YanBACKGROUND: Wuwei City has the highest prevalence of hepatitis B virus (HBV) in China. From 2007 to 2011, the average reported incidence rate of hepatitis B was 634.56/100,000 people. However, studies assessing the epidemic features and risk factors of HCV in the general population of Wuwei City are limited. METHODS: A total of 7189 people were interviewed and screened for HCV antibodies. HCV RNA and HCV genotypes were analyzed by PCR. Relevant information was obtained from the general population using a standardized questionnaire, and association and logistic regression analyses were conducted. RESULTS: The anti-HCV prevalence was 1.64% (118/7189), and HCV-RNA was detected in 37.29% (44/118) of the anti-HCV positive samples. The current HCV infection rate was 0.61% (44/7189) in the Wuwei general population. Hepatitis C infection rate was generally higher in the plains regions (χ(2) = 27.54,P<0.05), and the most predominant HCV genotypes were 2a (59.1%) and 1b (34.1%). The concurrent HCV and HBV infection rate was 1.37%, and a history of blood transfusion (OR = 17.9, 95% CI: 6.1 to 52.6, p<0.001) was an independent risk factor for HCV positivity. CONCLUSIONS: Although Wuwei is a highly endemic area for HBV, the anti-HCV positive rate in the general population is low. More than one-third of HCV-infected people were unaware of their infection; this may become an important risk factor for hepatitis C prevalence in the general population. Maintaining blood safety is important in order to help reduce the burden of HCV infection in developing regions of China.http://europepmc.org/articles/PMC3555996?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Duan Li Yong Long Tingcai Wang Dan Xiao Jingxia Zhang Zhiwen Guo Bo Wang Yongping Yan |
spellingShingle |
Duan Li Yong Long Tingcai Wang Dan Xiao Jingxia Zhang Zhiwen Guo Bo Wang Yongping Yan Epidemiology of hepatitis C virus infection in highly endemic HBV areas in China. PLoS ONE |
author_facet |
Duan Li Yong Long Tingcai Wang Dan Xiao Jingxia Zhang Zhiwen Guo Bo Wang Yongping Yan |
author_sort |
Duan Li |
title |
Epidemiology of hepatitis C virus infection in highly endemic HBV areas in China. |
title_short |
Epidemiology of hepatitis C virus infection in highly endemic HBV areas in China. |
title_full |
Epidemiology of hepatitis C virus infection in highly endemic HBV areas in China. |
title_fullStr |
Epidemiology of hepatitis C virus infection in highly endemic HBV areas in China. |
title_full_unstemmed |
Epidemiology of hepatitis C virus infection in highly endemic HBV areas in China. |
title_sort |
epidemiology of hepatitis c virus infection in highly endemic hbv areas in china. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2013-01-01 |
description |
BACKGROUND: Wuwei City has the highest prevalence of hepatitis B virus (HBV) in China. From 2007 to 2011, the average reported incidence rate of hepatitis B was 634.56/100,000 people. However, studies assessing the epidemic features and risk factors of HCV in the general population of Wuwei City are limited. METHODS: A total of 7189 people were interviewed and screened for HCV antibodies. HCV RNA and HCV genotypes were analyzed by PCR. Relevant information was obtained from the general population using a standardized questionnaire, and association and logistic regression analyses were conducted. RESULTS: The anti-HCV prevalence was 1.64% (118/7189), and HCV-RNA was detected in 37.29% (44/118) of the anti-HCV positive samples. The current HCV infection rate was 0.61% (44/7189) in the Wuwei general population. Hepatitis C infection rate was generally higher in the plains regions (χ(2) = 27.54,P<0.05), and the most predominant HCV genotypes were 2a (59.1%) and 1b (34.1%). The concurrent HCV and HBV infection rate was 1.37%, and a history of blood transfusion (OR = 17.9, 95% CI: 6.1 to 52.6, p<0.001) was an independent risk factor for HCV positivity. CONCLUSIONS: Although Wuwei is a highly endemic area for HBV, the anti-HCV positive rate in the general population is low. More than one-third of HCV-infected people were unaware of their infection; this may become an important risk factor for hepatitis C prevalence in the general population. Maintaining blood safety is important in order to help reduce the burden of HCV infection in developing regions of China. |
url |
http://europepmc.org/articles/PMC3555996?pdf=render |
work_keys_str_mv |
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