Design and evaluation of nicorandil extended-release tablet

• Main Authors: Ju-Young Kim, Chun-Woong Park, Beom-Jin Lee, Eun-Seok Park, Yun-Seok Rhee
• Format: Article
• Language: English
• Published: Elsevier 2015-04-01
• Series: Asian Journal of Pharmaceutical Sciences
• Subjects: Nicorandil; In vitro; In vivo; Pharmacokinetic; Extended-release
• Online Access: http://www.sciencedirect.com/science/article/pii/S1818087614000713

The aim of this study was to design and evaluate extended-release formulations of a model drug, nicorandil, in order to achieve the desired steady-state plasma concentration of drug in vivo. Simulation was employed to estimate optimum dissolution and absorption rate of nicorandil. The dissolution test was employed using pH 1.2, 4.0, 6.8 buffer solution, or water, to measure the in vitro release behaviors of nicorandil formulations. A single dose (15 mg) of each formulation was orally administered to four beagle dogs under fasted conditions, and the pharmacokinetic parameters were calculated. The in vitro/in vivo relationship of the extended-release formulation was confirmed using in vitro dissolution profiles and plasma concentrations of drug in beagle dogs. Nicorandil was released completely within 30 min from the immediate-release tablets and released for 24 h from the extended-release tablets. The nicorandil plasma concentration could be modified by adjusting the drug release rate from the extended-release formulation. The release rate of nicorandil was the rate-limiting step in the overall absorption of drug from the extended-release formulations. These results highlight the potential of a nicorandil extended-release formulation in the treatment of angina pectoris.