Errors in protein synthesis increase the level of saturated fatty acids and affect the overall lipid profiles of yeast.

Errors in protein synthesis increase the level of saturated fatty acids and affect the overall lipid profiles of yeast.

The occurrence of protein synthesis errors (mistranslation) above the typical mean mistranslation level of 10-4 is mostly deleterious to yeast, zebrafish and mammal cells. Previous yeast studies have shown that mistranslation affects fitness and deregulates genes related to lipid metabolism, but the...

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Bibliographic Details
Main Authors: Ana Rita D Araújo, Tânia Melo, Elisabete A Maciel, Clara Pereira, Catarina M Morais, Deolinda R Santinha, Joana F Tavares, Helena Oliveira, Amália S Jurado, Vítor Costa, Pedro Domingues, Maria Rosário M Domingues, Manuel A S Santos
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6110467?pdf=render

Internet

http://europepmc.org/articles/PMC6110467?pdf=render

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