The Essential Role Played by B Cells in Supporting Protective Immunity Against Trichuris muris Infection Is by Controlling the Th1/Th2 Balance in the Mesenteric Lymph Nodes and Depends on Host Genetic Background

The Essential Role Played by B Cells in Supporting Protective Immunity Against Trichuris muris Infection Is by Controlling the Th1/Th2 Balance in the Mesenteric Lymph Nodes and Depends on Host Genetic Background

How B cells contribute to protective immunity against parasitic nematodes remains unclear, with their importance as accessory cells underexplored. In this study, anti-CD20 monoclonal antibody (α-CD20 mAb)-mediated depletion of B cells from C57BL/6 mice revealed an important role for B cells in suppo...

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Bibliographic Details
Main Authors: Rinal Sahputra, Dominik Ruckerl, Kevin N. Couper, Werner Muller, Kathryn J. Else
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Immunology
Subjects:
B cells
Trichuris muris
anti-CD20 mAb
Th2 immunity
IFN-γ
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02842/full

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