α-Ketoglutarate Upregulates Collecting Duct (Pro)renin Receptor Expression, Tubular Angiotensin II Formation, and Na+ Reabsorption During High Glucose Conditions

α-Ketoglutarate Upregulates Collecting Duct (Pro)renin Receptor Expression, Tubular Angiotensin II Formation, and Na+ Reabsorption During High Glucose Conditions

Diabetes mellitus (DM) causes high glucose (HG) levels in the plasma and urine. The (pro)renin receptor (PRR) is a key regulator of renal Na+ handling. PRR is expressed in intercalated (IC) cells of the collecting duct (CD) and binds renin to promote angiotensin (Ang) II formation, thereby contribut...

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Bibliographic Details
Main Authors: Aarón Guerrero, Bruna Visniauskas, Pilar Cárdenas, Stefanny M. Figueroa, Jorge Vivanco, Nicolas Salinas-Parra, Patricio Araos, Quynh My Nguyen, Modar Kassan, Cristián A. Amador, Minolfa C. Prieto, Alexis A. Gonzalez
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
prorenin receptor
diabetes
angiotensin
collecting duct
Kreb's cycle
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.644797/full

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