Methotrexate induced lung injury in a patient with primary CNS lymphoma : A case report

• Main Authors: puneet chhabra, arjun dutt law, dr vikas suri, dr pankaj malhotra, dr subhash varma
• Format: Article
• Language: English
• Published: PAGEPress Publications 2012-01-01
• Series: Mediterranean Journal of Hematology and Infectious Diseases
• Subjects: methotrexate, lung in jury, primary CNS lymphoma
• Online Access: http://www.mjhid.org/article/view/9884

<p>Methotrexate is an antimetabolite commonly used in clinical practice for a variety of indications ranging from rheumatoid arthritis and other connective tissue disorders to high dose regimens in many malignancies. This folate antagonist has got a spectrum of toxicities among which gastrointestinal effects predominate . Lung injury is a well described but rare event and has been reported most often in patients who have been on long term oral therapy for rheumatic disorders. Acute lung injury in a patient receiving a high dose regimen for haematological malignancies has not been reported previously. We present one such case of methotrexate related acute lung injury in a patient of primary CNS lymphoma receiving high dose methotrexate.</p>