P5.20 MEASURE OF CHANGE IN CAROTID-RADIAL PULSE WAVE VELOCITY AFTER REACTIVE HYPERAEMIA

• Main Authors: Hakim Khettab*, Benjamin Nayagom, Sandrine Millasseau, Stephane Laurent, Pierre Boutouyrie
• Format: Article
• Language: English
• Published: Atlantis Press 2015-11-01
• Series: Artery Research
• Online Access: https://www.atlantis-press.com/article/125930623/view

The recognized reference method for endothelial function assessment is brachial artery diameter echo-tracking during flow mediated dilation (FMD) induced by reactive hyperaemia (RH). From the Mons-Korteweg equation, FMD should also reduce upper limb pulse wave velocity (PWV). The aim of our study was to compare echo-tracking FMD with PWV changes after RH. Brachial diameter was assessed by echo-tracking (MyLAb 70, Easote, Italy) before and after 7 min of ischemia induced by inflating a cuff on the right wirst 50mmHg above subject’s systolic blood pressure. Carotid-left radial and carotid-right radial PWVs were also simultaneously measured with Complior Analyse (Alam Medical, France) at baseline (in triplicate), 30sec, 1, 3 and 5 min end of ischemia. Measurements were performed in 15 healthy subjects (10M/5F, 31±11 yrs). Maximum PWV changes happened 1min after cuff deflation in the ischemic arm (ΔPWV=2,1±1,4m/s, p<0,001) while changes in the control arm were non-significant. Time after deflation ΔPWV ischemic arm ΔPWV control arm 30sec −0,6 ± 0,6 −0,2 ± 1,0 1min −2,1 ± 1,4 * −0,1 ± 1,1 3min −1,9 ± 1,4 * −0,1 ± 1,2 5min −1,7 ± 1,3 −0,7 ± 2,5 *p<0,001 The maximal change in arterial diameter post-RH was 5,1±4,7%. There was no correlation between diameter change and ΔPWV (R=0,03, p=0,91). While the use carotid-radial PWV seems promising to track changes post RH, further studies are needed to better understand this phenomena which is not related to diameter change.