Crystallization scale preparation of a stable GPCR signaling complex between constitutively active rhodopsin and G-protein.

Crystallization scale preparation of a stable GPCR signaling complex between constitutively active rhodopsin and G-protein.

The activation of the G-protein transducin (Gt) by rhodopsin (Rho) has been intensively studied for several decades. It is the best understood example of GPCR activation mechanism and serves as a template for other GPCRs. The structure of the Rho/G protein complex, which is transiently formed during...

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Bibliographic Details
Main Authors: Shoji Maeda, Dawei Sun, Ankita Singhal, Marcello Foggetta, Georg Schmid, Joerg Standfuss, Michael Hennig, Roger J P Dawson, Dmitry B Veprintsev, Gebhard F X Schertler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4076187?pdf=render

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