The Predictive Value of Tumor Mutation Burden on Efficacy of Immune Checkpoint Inhibitors in Cancers: A Systematic Review and Meta-Analysis

The Predictive Value of Tumor Mutation Burden on Efficacy of Immune Checkpoint Inhibitors in Cancers: A Systematic Review and Meta-Analysis

Background: Despite an increasing understanding about tumor mutation burden (TMB) in cancer immunity and cancer immunotherapy, the comprehensive cognition between TMB and efficiency of immune checkpoint inhibitors (ICIs) is still lacking. A systematic review and meta-analysis was conducted to evalua...

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Bibliographic Details
Main Authors: Yongfeng Wu, Jinming Xu, Chengli Du, Yihua Wu, Dajing Xia, Wang Lv, Jian Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Oncology
Subjects:
tumor mutation burden
tumor mutational burden
immune checkpoint inhibitors
objective response rate
progression-free survival
overall survival
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.01161/full

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