Latexin is down-regulated in hematopoietic malignancies and restoration of expression inhibits lymphoma growth.

Latexin is down-regulated in hematopoietic malignancies and restoration of expression inhibits lymphoma growth.

Latexin is a negative regulator of hematopoietic stem cell number in mice. Its dysregulated expression in other tumors led us to hypothesize that latexin may have tumor suppressor properties in hematological malignancies. We found that latexin was down-regulated in a variety of leukemia and lymphoma...

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Bibliographic Details
Main Authors: Yi Liu, Dianna Howard, Kyle Rector, Carol Swiderski, Jason Brandon, Lawrence Schook, Jayesh Mehta, J Scott Bryson, Subbarao Bondada, Ying Liang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3459965?pdf=render

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