Transcriptome analysis of potential candidate genes and molecular pathways in colitis-associated colorectal cancer of Mkp-1-deficient mice

Transcriptome analysis of potential candidate genes and molecular pathways in colitis-associated colorectal cancer of Mkp-1-deficient mice

Abstract Background The nuclear phosphatase mitogen-activate protein kinase phosphatase-1 (MKP-1) is a key negative regulator of the innate immune response through the regulation of the biosynthesis of proinflammatory cytokines. In colorectal cancer (CRC), which is induced mainly by chronic inflamma...

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Bibliographic Details
Main Authors: Ahmed Hammad, Zhao-Hong Zheng, Akhileshwar Namani, Mohamed Elshaer, Xiu Jun Wang, Xiuwen Tang
Format: Article
Language:English
Published: BMC 2021-05-01
Series:BMC Cancer
Subjects:
Mkp-1
Colitis
Colorectal cancer
RNA sequencing
Biomarker
Online Access:https://doi.org/10.1186/s12885-021-08200-0

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