Site-directed <it>in vitro </it>immunization leads to a complete human monoclonal IgG4λ that binds specifically to the CDR2 region of CTLA-4 (CD152) without interfering the engagement of natural ligands

Site-directed <it>in vitro </it>immunization leads to a complete human monoclonal IgG4λ that binds specifically to the CDR2 region of CTLA-4 (CD152) without interfering the engagement of natural ligands

<p>Abstract</p> <p>Background</p> <p>The ability to acquire fully human monoclonal antibodies (mAbs) with pre-defined specificities is critical to the development of molecular tags for the analysis of receptor function in addition to promising immunotherapeutics. Yet mo...

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Bibliographic Details
Main Authors: Hsu Shu-Ching, Chen Han-Min, Chu Chishih, Chin Li-Te, Weng Bor-Chun, Chu Chi-Hong
Format: Article
Language:English
Published: BMC 2007-08-01
Series:BMC Biotechnology
Online Access:http://www.biomedcentral.com/1472-6750/7/51

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