Improving the Realism of White Matter Numerical Phantoms: A Step toward a Better Understanding of the Influence of Structural Disorders in Diffusion MRI
White matter is composed of irregularly packed axons leading to a structural disorder in the extra-axonal space. Diffusion MRI experiments using oscillating gradient spin echo sequences have shown that the diffusivity transverse to axons in this extra-axonal space is dependent on the frequency of th...
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doaj-8b017fa9e03d4ca195a9eb0c85fc3be12020-11-25T00:12:50ZengFrontiers Media S.A.Frontiers in Physics2296-424X2018-02-01610.3389/fphy.2018.00012334547Improving the Realism of White Matter Numerical Phantoms: A Step toward a Better Understanding of the Influence of Structural Disorders in Diffusion MRIKévin Ginsburger0Kévin Ginsburger1Fabrice Poupon2Fabrice Poupon3Justine Beaujoin4Justine Beaujoin5Delphine Estournet6Delphine Estournet7Felix Matuschke8Jean-François Mangin9Jean-François Mangin10Jean-François Mangin11Markus Axer12Cyril Poupon13Cyril Poupon14CEA DRF/ISVFJ/Neurospin/UNIRS, Gif-sur-Yvette, FranceUniversité Paris-Saclay, Orsay, FranceUniversité Paris-Saclay, Orsay, FranceCEA DRF/ISVFJ/Neurospin/UNATI, Gif-sur-Yvette, FranceCEA DRF/ISVFJ/Neurospin/UNIRS, Gif-sur-Yvette, FranceUniversité Paris-Saclay, Orsay, FranceCEA DRF/ISVFJ/Neurospin/UNIRS, Gif-sur-Yvette, FranceUniversité Paris-Saclay, Orsay, FranceResearch Centre Jülich, Institute of Neuroscience and Medicine, Jülich, GermanyUniversité Paris-Saclay, Orsay, FranceCEA DRF/ISVFJ/Neurospin/UNATI, Gif-sur-Yvette, FranceCATI, Multicenter Neuroimaging Platform, Orsay, FranceResearch Centre Jülich, Institute of Neuroscience and Medicine, Jülich, GermanyCEA DRF/ISVFJ/Neurospin/UNIRS, Gif-sur-Yvette, FranceUniversité Paris-Saclay, Orsay, FranceWhite matter is composed of irregularly packed axons leading to a structural disorder in the extra-axonal space. Diffusion MRI experiments using oscillating gradient spin echo sequences have shown that the diffusivity transverse to axons in this extra-axonal space is dependent on the frequency of the employed sequence. In this study, we observe the same frequency-dependence using 3D simulations of the diffusion process in disordered media. We design a novel white matter numerical phantom generation algorithm which constructs biomimicking geometric configurations with few design parameters, and enables to control the level of disorder of the generated phantoms. The influence of various geometrical parameters present in white matter, such as global angular dispersion, tortuosity, presence of Ranvier nodes, beading, on the extra-cellular perpendicular diffusivity frequency dependence was investigated by simulating the diffusion process in numerical phantoms of increasing complexity and fitting the resulting simulated diffusion MR signal attenuation with an adequate analytical model designed for trapezoidal OGSE sequences.This work suggests that angular dispersion and especially beading have non-negligible effects on this extracellular diffusion metrics that may be measured using standard OGSE DW-MRI clinical protocols.http://journal.frontiersin.org/article/10.3389/fphy.2018.00012/fulldiffusion time-dependencewhite matter microstructuretrapezoidal OGSE sequencesaxonal diameterMonte-Carlo simulationsbiomimicking numerical phantoms |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kévin Ginsburger Kévin Ginsburger Fabrice Poupon Fabrice Poupon Justine Beaujoin Justine Beaujoin Delphine Estournet Delphine Estournet Felix Matuschke Jean-François Mangin Jean-François Mangin Jean-François Mangin Markus Axer Cyril Poupon Cyril Poupon |
spellingShingle |
Kévin Ginsburger Kévin Ginsburger Fabrice Poupon Fabrice Poupon Justine Beaujoin Justine Beaujoin Delphine Estournet Delphine Estournet Felix Matuschke Jean-François Mangin Jean-François Mangin Jean-François Mangin Markus Axer Cyril Poupon Cyril Poupon Improving the Realism of White Matter Numerical Phantoms: A Step toward a Better Understanding of the Influence of Structural Disorders in Diffusion MRI Frontiers in Physics diffusion time-dependence white matter microstructure trapezoidal OGSE sequences axonal diameter Monte-Carlo simulations biomimicking numerical phantoms |
author_facet |
Kévin Ginsburger Kévin Ginsburger Fabrice Poupon Fabrice Poupon Justine Beaujoin Justine Beaujoin Delphine Estournet Delphine Estournet Felix Matuschke Jean-François Mangin Jean-François Mangin Jean-François Mangin Markus Axer Cyril Poupon Cyril Poupon |
author_sort |
Kévin Ginsburger |
title |
Improving the Realism of White Matter Numerical Phantoms: A Step toward a Better Understanding of the Influence of Structural Disorders in Diffusion MRI |
title_short |
Improving the Realism of White Matter Numerical Phantoms: A Step toward a Better Understanding of the Influence of Structural Disorders in Diffusion MRI |
title_full |
Improving the Realism of White Matter Numerical Phantoms: A Step toward a Better Understanding of the Influence of Structural Disorders in Diffusion MRI |
title_fullStr |
Improving the Realism of White Matter Numerical Phantoms: A Step toward a Better Understanding of the Influence of Structural Disorders in Diffusion MRI |
title_full_unstemmed |
Improving the Realism of White Matter Numerical Phantoms: A Step toward a Better Understanding of the Influence of Structural Disorders in Diffusion MRI |
title_sort |
improving the realism of white matter numerical phantoms: a step toward a better understanding of the influence of structural disorders in diffusion mri |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Physics |
issn |
2296-424X |
publishDate |
2018-02-01 |
description |
White matter is composed of irregularly packed axons leading to a structural disorder in the extra-axonal space. Diffusion MRI experiments using oscillating gradient spin echo sequences have shown that the diffusivity transverse to axons in this extra-axonal space is dependent on the frequency of the employed sequence. In this study, we observe the same frequency-dependence using 3D simulations of the diffusion process in disordered media. We design a novel white matter numerical phantom generation algorithm which constructs biomimicking geometric configurations with few design parameters, and enables to control the level of disorder of the generated phantoms. The influence of various geometrical parameters present in white matter, such as global angular dispersion, tortuosity, presence of Ranvier nodes, beading, on the extra-cellular perpendicular diffusivity frequency dependence was investigated by simulating the diffusion process in numerical phantoms of increasing complexity and fitting the resulting simulated diffusion MR signal attenuation with an adequate analytical model designed for trapezoidal OGSE sequences.This work suggests that angular dispersion and especially beading have non-negligible effects on this extracellular diffusion metrics that may be measured using standard OGSE DW-MRI clinical protocols. |
topic |
diffusion time-dependence white matter microstructure trapezoidal OGSE sequences axonal diameter Monte-Carlo simulations biomimicking numerical phantoms |
url |
http://journal.frontiersin.org/article/10.3389/fphy.2018.00012/full |
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