Strand break-induced replication fork collapse leads to C-circles, C-overhangs and telomeric recombination.

Strand break-induced replication fork collapse leads to C-circles, C-overhangs and telomeric recombination.

Telomerase-independent ALT (alternative lengthening of telomeres) cells are characterized by high frequency of telomeric homologous recombination (HR), C-rich extrachromosomal circles (C-circles) and C-rich terminal 5' overhangs (C-overhangs). However, underlying mechanism is poorly understood....

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Bibliographic Details
Main Authors: Tianpeng Zhang, Zepeng Zhang, Gong Shengzhao, Xiaocui Li, Haiying Liu, Yong Zhao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-02-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1007925

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