Plant stanol ethers: perspectives and effects in non-pharmaceutical prevention of atherosclerotic cardiovascular pathology
Reduction in total cholesterol (TCH) and low-density lipoprotein CH (LDL-CH) levels while taking food products enriched in plant stanol ethers (PSE) might be explained by inhibited intestine enterocyte CH absorption. PSE inhibit both food and biliary CH absorption. Unsaturated fatty acid-etherized s...
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2006-12-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/1412 |
| Summary: | Reduction in total cholesterol (TCH) and low-density lipoprotein CH (LDL-CH) levels while taking food products enriched in plant stanol ethers (PSE) might be explained by inhibited intestine enterocyte CH absorption. PSE inhibit both food and biliary CH absorption. Unsaturated fatty acid-etherized stanols are well-soluble in high-fat foods (spreads), as well as in low-fat products (milk, kefir, yogurts, etc.). Serum TCH and LDL-CH levels are effectively reduced (by 7-10% and 12-15%, respectively) with PSE doses of 1,6-2,8 g/d. In hypercholesterolemia (HCH) patients receiving CH synthesis inhibitors – statins, PSE-enriched food intake associates with additional LDL-CH decrease by 10-20%. PSE-enriched “functional” products might be widely used for non-pharmaceutical HCH treatment and cardiovascular prevention on population level. |
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| ISSN: | 1728-8800 2619-0125 |