Fibronectin content in cervical ripening and placenta tissue and its correlation with preterm-related molecule expression

• Main Authors: Nian-Fang Chen, Jian-Fang Zhong, Hua-Chun Lan, Fen-Lan Wang
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2016-07-01
• Series: Journal of Hainan Medical University
• Subjects: Premature delivery; Fetal fibronectin; Inflammatory factors; Matrix metalloproteinases
• Online Access: http://www.hnykdxxb.com/PDF/201614/28.pdf
• ISSN: 1007-1237; 1007-1237

Objective: To study fibronectin content in cervical ripening and placenta tissue and its correlation with preterm-related molecule expression. Methods: A total of 60 women with preterm delivery and 60 women with term delivery who delivered in Obstetrics Department of our hospital from June 2014 to June 2015 were selected and divided into preterm group and control group respectively. Cervical ripening was collected to detect fFN content, placenta was collected to detect fFN, SOCS, TLR4 and NF-毷B content, serum was collected to detect MMP2, MMP3, MMP9, IL-2, IL-6 and TNF-毩 content, and cervical length was measured by ultrasound. Results: fFN content significantly increased in cervical ripening of preterm group while difference of fFN content in placenta was not significant; cervical length as well as serum MMP2, MMP3, MMP9, IL-2, IL-6 and TNF-毩 content in cervical ripening of fFNpositive patients were significantly higher than those of fFN-negative patients, TLR4 and NF-κB content in placenta were significantly higher than those in cervical ripening of fFNnegative patients, and SOCS3 content was significantly lower than that in cervical ripening of fFN-negative patients. Conclusions: Increase of fFN content in cervical ripening can increase the expression of matrix metalloproteinases and inflammatory factors through TLR4/NF-κB pathway and SOCS3 pathway, thereby leading to premature delivery.