SOD2 ameliorates pulmonary hypertension in a murine model of sleep apnea via suppressing expression of NLRP3 in CD11b+ cells

SOD2 ameliorates pulmonary hypertension in a murine model of sleep apnea via suppressing expression of NLRP3 in CD11b+ cells

Abstract Background High prevalence of obstructive sleep apnea (OSA) in the pulmonary hypertension (PH) population suggests that chronic intermittent hypoxia (CIH) is an important pathogenic factor of PH. However, the exact mechanism of CIH induced PH is not clear. One of the molecules that plays a...

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Bibliographic Details
Main Authors: Cuiping Fu, Shengyu Hao, Zilong Liu, Liang Xie, Xu Wu, Xiaodan Wu, Shanqun Li
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Respiratory Research
Subjects:
Chronic intermittent hypoxia
Pulmonary hypertension
SOD2
NLRP3
CD11b
Online Access:https://doi.org/10.1186/s12931-019-1270-0

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