Disruption of Imprinted Genes at Chromosome Region 11p15.5 in Paediatric Rhabdomyosarcoma

Disruption of Imprinted Genes at Chromosome Region 11p15.5 in Paediatric Rhabdomyosarcoma

Rhabdomyosarcomas are characterized by loss of heterozygosity (LOH) at chromosome region 11pl5.5, a region known to contain several imprinted genes including insulin-like growth factor 2 (IGF2), H19, p57KIP2. We analyzed 48 primary tumour samples and found distinct genetic changes at 11p15.5 in alv...

Full description

Bibliographic Details
Main Authors: John Anderson, Anthony Gordon, Aidan McManus, Janet Shipley, Kathy Pritchard-Jones
Format: Article
Language:English
Published: Elsevier 1999-10-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
rhabdomyosarcoma
imprinting
H19
insulin-like growth factor 2
p57KIP2
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558699800256

Similar Items

Similar Items