Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment

Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment

Inflammation can be induced by obesity, and has been linked with onset of colorectal cancer (CAC). Here the authors show in mouse models that obesity-induced interleukin-6 alters macrophage function to enhance CCL-20/CCR-6-mediated recruitment of B cells and γδ T cells, thereby promoting gut inflamm...

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Main Authors: Claudia M. Wunderlich, P. Justus Ackermann, Anna Lena Ostermann, Petra Adams-Quack, Merly C. Vogt, My-Ly Tran, Alexei Nikolajev, Ari Waisman, Christoph Garbers, Sebastian Theurich, Jan Mauer, Nadine Hövelmeyer, F. Thomas Wunderlich
Format: Article
Language:English
Published: Nature Publishing Group 2018-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03773-0
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spelling doaj-8aa769939cda447285b994dfedfa88952021-05-11T10:07:02ZengNature Publishing GroupNature Communications2041-17232018-04-019111610.1038/s41467-018-03773-0Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitmentClaudia M. Wunderlich0P. Justus Ackermann1Anna Lena Ostermann2Petra Adams-Quack3Merly C. Vogt4My-Ly Tran5Alexei Nikolajev6Ari Waisman7Christoph Garbers8Sebastian Theurich9Jan Mauer10Nadine Hövelmeyer11F. Thomas Wunderlich12Max Planck Institute for Metabolism Research Cologne, Institute for Genetics, University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), Center for Endocrinology, Diabetes and Preventive Medicine (CEDP) CologneMax Planck Institute for Metabolism Research Cologne, Institute for Genetics, University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), Center for Endocrinology, Diabetes and Preventive Medicine (CEDP) CologneMax Planck Institute for Metabolism Research Cologne, Institute for Genetics, University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), Center for Endocrinology, Diabetes and Preventive Medicine (CEDP) CologneInstitute for Molecular Medicine, University Hospital MainzMax Planck Institute for Metabolism Research Cologne, Institute for Genetics, University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), Center for Endocrinology, Diabetes and Preventive Medicine (CEDP) CologneMax Planck Institute for Metabolism Research Cologne, Institute for Genetics, University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), Center for Endocrinology, Diabetes and Preventive Medicine (CEDP) CologneInstitute for Molecular Medicine, University Hospital MainzInstitute for Molecular Medicine, University Hospital MainzDepartment of Biochemistry, Kiel University, Medical FacultyMax Planck Institute for Metabolism Research Cologne, Institute for Genetics, University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), Center for Endocrinology, Diabetes and Preventive Medicine (CEDP) CologneDepartment of Pharmacology, Weill Cornell Medical College, Cornell UniversityInstitute for Molecular Medicine, University Hospital MainzMax Planck Institute for Metabolism Research Cologne, Institute for Genetics, University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), Center for Endocrinology, Diabetes and Preventive Medicine (CEDP) CologneInflammation can be induced by obesity, and has been linked with onset of colorectal cancer (CAC). Here the authors show in mouse models that obesity-induced interleukin-6 alters macrophage function to enhance CCL-20/CCR-6-mediated recruitment of B cells and γδ T cells, thereby promoting gut inflammation and CAC progression.https://doi.org/10.1038/s41467-018-03773-0
collection DOAJ
language English
format Article
sources DOAJ
author Claudia M. Wunderlich
P. Justus Ackermann
Anna Lena Ostermann
Petra Adams-Quack
Merly C. Vogt
My-Ly Tran
Alexei Nikolajev
Ari Waisman
Christoph Garbers
Sebastian Theurich
Jan Mauer
Nadine Hövelmeyer
F. Thomas Wunderlich
spellingShingle Claudia M. Wunderlich
P. Justus Ackermann
Anna Lena Ostermann
Petra Adams-Quack
Merly C. Vogt
My-Ly Tran
Alexei Nikolajev
Ari Waisman
Christoph Garbers
Sebastian Theurich
Jan Mauer
Nadine Hövelmeyer
F. Thomas Wunderlich
Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment
Nature Communications
author_facet Claudia M. Wunderlich
P. Justus Ackermann
Anna Lena Ostermann
Petra Adams-Quack
Merly C. Vogt
My-Ly Tran
Alexei Nikolajev
Ari Waisman
Christoph Garbers
Sebastian Theurich
Jan Mauer
Nadine Hövelmeyer
F. Thomas Wunderlich
author_sort Claudia M. Wunderlich
title Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment
title_short Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment
title_full Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment
title_fullStr Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment
title_full_unstemmed Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment
title_sort obesity exacerbates colitis-associated cancer via il-6-regulated macrophage polarisation and ccl-20/ccr-6-mediated lymphocyte recruitment
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-04-01
description Inflammation can be induced by obesity, and has been linked with onset of colorectal cancer (CAC). Here the authors show in mouse models that obesity-induced interleukin-6 alters macrophage function to enhance CCL-20/CCR-6-mediated recruitment of B cells and γδ T cells, thereby promoting gut inflammation and CAC progression.
url https://doi.org/10.1038/s41467-018-03773-0
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