Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment
Inflammation can be induced by obesity, and has been linked with onset of colorectal cancer (CAC). Here the authors show in mouse models that obesity-induced interleukin-6 alters macrophage function to enhance CCL-20/CCR-6-mediated recruitment of B cells and γδ T cells, thereby promoting gut inflamm...
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Bibliographic Details
| Main Authors: |
Claudia M. Wunderlich,
P. Justus Ackermann,
Anna Lena Ostermann,
Petra Adams-Quack,
Merly C. Vogt,
My-Ly Tran,
Alexei Nikolajev,
Ari Waisman,
Christoph Garbers,
Sebastian Theurich,
Jan Mauer,
Nadine Hövelmeyer,
F. Thomas Wunderlich |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2018-04-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-018-03773-0
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