Effect of Caloric Restriction on the in vivo Functional Properties of Aging Microglia

Effect of Caloric Restriction on the in vivo Functional Properties of Aging Microglia

Throughout the lifespan, microglia, the primary innate immune cells of the brain, fulfill a plethora of homeostatic as well as active immune defense functions, and their aging-induced dysfunctionality is now considered as a key trigger of aging-related brain disorders. Recent evidence suggests that...

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Bibliographic Details
Main Authors: Maria Olmedillas del Moral, Nicole Fröhlich, Katherine Figarella, Nima Mojtahedi, Olga Garaschuk
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Immunology
Subjects:
caloric restriction
microglia
aging
sex differences
in vivo Cacpsdummy2+ imaging
process motility
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00750/full

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