Multifocal Medulloblastoma in an Adult Patient: Description of a Rare Presentation and Review of the Literature

Medulloblastoma is an embryonal neuroepithelial tumor that affects mainly childhood and more rarely adults. Medulloblastoma occurring as multiple nodules at diagnosis is a rare and tricky presentation. Here, we describe the case of a previously healthy 47-year-old woman with multiple posterior fossa...

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Main Authors:	Irene Troncon, Angela Guerriero, Sabrina Rossi, Monica Ronzon, Marta Padovan, Caccese Mario, Lucia Zanatta, Luisa Toffolatti, Elisabetta Marton, Giuseppe Lombardi, Angelo Paolo Dei Tos, Giuseppe Canova
Format:	Article
Language:	English
Published:	Hindawi Limited 2020-01-01
Series:	Case Reports in Pathology
Online Access:	http://dx.doi.org/10.1155/2020/4502878

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spelling	doaj-8a81073c3410473a916b3b3e79d4f7012020-12-14T01:31:11ZengHindawi LimitedCase Reports in Pathology2090-679X2020-01-01202010.1155/2020/45028784502878Multifocal Medulloblastoma in an Adult Patient: Description of a Rare Presentation and Review of the LiteratureIrene Troncon0Angela Guerriero1Sabrina Rossi2Monica Ronzon3Marta Padovan4Caccese Mario5Lucia Zanatta6Luisa Toffolatti7Elisabetta Marton8Giuseppe Lombardi9Angelo Paolo Dei Tos10Giuseppe Canova11Department of NeurosurgeryDepartment of Pathology and Molecular GeneticsDepartment of PathologyDepartment of NeuroradiologyDepartment of OncologyDepartment of OncologyDepartment of Pathology and Molecular GeneticsDepartment of Pathology and Molecular GeneticsDepartment of Neurologic SurgeryDepartment of OncologyDepartment of Pathology and Molecular GeneticsDepartment of Neurologic SurgeryMedulloblastoma is an embryonal neuroepithelial tumor that affects mainly childhood and more rarely adults. Medulloblastoma occurring as multiple nodules at diagnosis is a rare and tricky presentation. Here, we describe the case of a previously healthy 47-year-old woman with multiple posterior fossa cerebellar tumors. Histological, immunohistochemical, and molecular analyses were performed to best characterize the two excised lesions. The histopathological analysis revealed different variants of medulloblastoma in the excised nodules, one being extensive nodularity, rare in adults, and the other desmoplastic/nodular with areas of anaplasia. Immunostains and molecular analysis classified both nodules as SHH medulloblastoma. Adult medulloblastoma is extremely rare. Important differences exist between adult medulloblastoma and medulloblastoma arising in children and infants. Such differences are in location, distribution of histological variants and of molecular subgroups, survival rates, and therapeutic options. An extensive morphological and molecular characterization of such rare tumors is necessary to choice the best-tailored therapy.http://dx.doi.org/10.1155/2020/4502878
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Irene Troncon Angela Guerriero Sabrina Rossi Monica Ronzon Marta Padovan Caccese Mario Lucia Zanatta Luisa Toffolatti Elisabetta Marton Giuseppe Lombardi Angelo Paolo Dei Tos Giuseppe Canova
spellingShingle	Irene Troncon Angela Guerriero Sabrina Rossi Monica Ronzon Marta Padovan Caccese Mario Lucia Zanatta Luisa Toffolatti Elisabetta Marton Giuseppe Lombardi Angelo Paolo Dei Tos Giuseppe Canova Multifocal Medulloblastoma in an Adult Patient: Description of a Rare Presentation and Review of the Literature Case Reports in Pathology
author_facet	Irene Troncon Angela Guerriero Sabrina Rossi Monica Ronzon Marta Padovan Caccese Mario Lucia Zanatta Luisa Toffolatti Elisabetta Marton Giuseppe Lombardi Angelo Paolo Dei Tos Giuseppe Canova
author_sort	Irene Troncon
title	Multifocal Medulloblastoma in an Adult Patient: Description of a Rare Presentation and Review of the Literature
title_short	Multifocal Medulloblastoma in an Adult Patient: Description of a Rare Presentation and Review of the Literature
title_full	Multifocal Medulloblastoma in an Adult Patient: Description of a Rare Presentation and Review of the Literature
title_fullStr	Multifocal Medulloblastoma in an Adult Patient: Description of a Rare Presentation and Review of the Literature
title_full_unstemmed	Multifocal Medulloblastoma in an Adult Patient: Description of a Rare Presentation and Review of the Literature
title_sort	multifocal medulloblastoma in an adult patient: description of a rare presentation and review of the literature
publisher	Hindawi Limited
series	Case Reports in Pathology
issn	2090-679X
publishDate	2020-01-01
description	Medulloblastoma is an embryonal neuroepithelial tumor that affects mainly childhood and more rarely adults. Medulloblastoma occurring as multiple nodules at diagnosis is a rare and tricky presentation. Here, we describe the case of a previously healthy 47-year-old woman with multiple posterior fossa cerebellar tumors. Histological, immunohistochemical, and molecular analyses were performed to best characterize the two excised lesions. The histopathological analysis revealed different variants of medulloblastoma in the excised nodules, one being extensive nodularity, rare in adults, and the other desmoplastic/nodular with areas of anaplasia. Immunostains and molecular analysis classified both nodules as SHH medulloblastoma. Adult medulloblastoma is extremely rare. Important differences exist between adult medulloblastoma and medulloblastoma arising in children and infants. Such differences are in location, distribution of histological variants and of molecular subgroups, survival rates, and therapeutic options. An extensive morphological and molecular characterization of such rare tumors is necessary to choice the best-tailored therapy.
url	http://dx.doi.org/10.1155/2020/4502878
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Multifocal Medulloblastoma in an Adult Patient: Description of a Rare Presentation and Review of the Literature

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