Secondary analysis of malaria rapid diagnostic tests from rounds 5–8 of WHO product testing with a focus on false-negative results

Secondary analysis of malaria rapid diagnostic tests from rounds 5–8 of WHO product testing with a focus on false-negative results

Abstract Despite the widespread use of malaria rapid diagnostic test (RDT) in clinical practice, there are a lot of challenges. We conducted a secondary analysis of 129 malaria RDT data from rounds 5–8 of the World Health Organization (WHO) product testing summary and discuss the causes of false-neg...

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Bibliographic Details
Main Authors: Biao Xu, Bo Tu, Fang Chu, Mohamed Jalloh, Jin-Song Mu, Jun-Jie Zheng, Wei-Wei Chen
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Military Medical Research
Subjects:
Malaria
Rapid diagnostic tests
False-negative results
WHO product testing
Online Access:https://doi.org/10.1186/s40779-021-00345-0
Description
Summary:Abstract Despite the widespread use of malaria rapid diagnostic test (RDT) in clinical practice, there are a lot of challenges. We conducted a secondary analysis of 129 malaria RDT data from rounds 5–8 of the World Health Organization (WHO) product testing summary and discuss the causes of false-negative (FN) results with a focus on low parasite density, improper RDT storage, operation and interpretation, and plasmodium falciparum with a pfhrp2/3 gene deletion. The results demonstrated that the malaria RDTs currently commercially available might cause FN results in practice.
ISSN:2054-9369

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