Genome wide identification of recessive cancer genes by combinatorial mutation analysis.

Genome wide identification of recessive cancer genes by combinatorial mutation analysis.

We devised a novel procedure to identify human cancer genes acting in a recessive manner. Our strategy was to combine the contributions of the different types of genetic alterations to loss of function: amino-acid substitutions, frame-shifts, gene deletions. We studied over 20,000 genes in 3 Gigabas...

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Bibliographic Details
Main Authors:	Stefano Volinia, Nicoletta Mascellani, Jlenia Marchesini, Angelo Veronese, Elizabeth Ormondroyd, Hansjuerg Alder, Jeff Palatini, Massimo Negrini, Carlo M Croce
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2008-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC2557123?pdf=render

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