Pioglitazone Improves Mitochondrial Organization and Bioenergetics in Down Syndrome Cells

Pioglitazone Improves Mitochondrial Organization and Bioenergetics in Down Syndrome Cells

Mitochondrial dysfunction plays a primary role in neurodevelopmental anomalies and neurodegeneration of Down syndrome (DS) subjects. For this reason, targeting mitochondrial key genes, such as PGC-1α/PPARGC1A, is emerging as a good therapeutic approach to attenuate cognitive disability in DS. After...

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Bibliographic Details
Main Authors: Nunzia Mollo, Maria Nitti, Lucrezia Zerillo, Deriggio Faicchia, Teresa Micillo, Rossella Accarino, Agnese Secondo, Tiziana Petrozziello, Gaetano Calì, Rita Cicatiello, Ferdinando Bonfiglio, Viviana Sarnataro, Rita Genesio, Antonella Izzo, Paolo Pinton, Giuseppe Matarese, Simona Paladino, Anna Conti, Lucio Nitsch
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Genetics
Subjects:
Down syndrome/therapy
pioglitazone
energy metabolism
oxidative stress
mitochondrial dysfunction
mitochondrial dynamics
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00606/full

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