Hypocaloric diet in thrombosis risk reduction among patients with arterial hypertension and metabolic syndrome

• Main Author: I. N. Medvedev
• Format: Article
• Language: Russian
• Published: «FIRMA «SILICEA» LLC 2006-02-01
• Series: Российский кардиологический журнал
• Subjects: arterial hypertension; abdominal obesity; impaired glucose tolerance; platelets; hypocaloric diet
• Online Access: https://russjcardiol.elpub.ru/jour/article/view/1694
• ISSN: 1560-4071; 2618-7620

The aim of the study was to assess hypocaloric diet effects on platelet aggregation and their mechanisms in patients with arterial hypertension (AH), android obesity (AO), and impaired glucose tolerance (IGT). In total, 25 middle;aged patients with AH, AO and IGT were examined. Anthropometry, assessment of lipid profile, plasma and platelet lipid peroxidation, and platelet hemostasis were performed. All participants received hypocaloric diet for 24 weeks. In patients with AH, AO and IGT, hypocaloric diet improved lipid profile, suppressed peroxidation syndrome, beneficial; ly influenced intra;platelet aggregation mechanisms. Hypocaloric diet also decreased in vitro platelet adhesion and aggrega;tion, especially by the end of 24;week intervention, even though control levels were not achieved. Conclusion. For adequate correction of metabolism and platelet hemostasis in patients with AH, AO and IGT, isolated administration of hypocaloric diet is not enough. Other therapeutic approaches are needed for individuals with AH, AO and IGT.