Immunostimulatory activity of <it>Stachys mialhesi</it> de Noé

• Main Authors: Benmebarek Assia, Zerizer Sakina, Laggoune Souheila, Kabouche Zahia
• Format: Article
• Language: English
• Published: BMC 2013-01-01
• Series: Allergy, Asthma & Clinical Immunology
• Subjects: Immunostimulatory activity; Phagocytic activity; Carbon clearance rate; Reticuloendothelial system; <it>Stachys mialhesi</it> de Noé
• Online Access: http://www.aacijournal.com/content/9/1/2

<p>Abstract</p> <p>Background</p> <p>Immunostimulatory therapy is now being recognized as an alternative to conventional chemotherapy for a variety of disease conditions, involving the impaired immune response of the host. In the present study, the immunostimulatory effect of the butanolic extract obtained from <it>S. mialhesi</it> aerial parts, was evaluated <it>in vivo</it>.</p> <p>Methods</p> <p>The immunostimulant potential of the plant extract on the phagocytic activity was measured by the carbon clearance rate test.</p> <p>Results</p> <p>Our research revealed that at different doses (50, 100 and 500 mg/kg), <it>S. mialhesi</it> extract increased the phagocytic activity in a dose dependant manner when compared with the control and thus the clearance rate of carbon was faster after the administration of the plant extract.</p> <p>Conclusion</p> <p><it>S. mialhesi</it> extract exhibited a dose-dependent immunostimulant effect on the reticuloendothelial system, which could be attributed to the presence of active principles in this butanolic extract.</p>