Effective Osteogenic Priming of Mesenchymal Stem Cells through LNA-ASOs-Mediated <i>Sfrp1</i> Gene Silencing

Effective Osteogenic Priming of Mesenchymal Stem Cells through LNA-ASOs-Mediated <i>Sfrp1</i> Gene Silencing

Mesenchymal stem cell (MSC) transplantation has emerged as a promising approach for bone regeneration. Importantly, the beneficial effects of MSCs can be improved by modulating the expression levels of specific genes to stimulate MSC osteogenic differentiation. We have previously shown that <i>...

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Bibliographic Details
Main Authors: Daniel García-Sánchez, Alberto González-González, Patricia García-García, Ricardo Reyes, María Isabel Pérez-Núñez, José A. Riancho, Carmen Évora, José Carlos Rodríguez-Rey, Flor M. Pérez-Campo
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Pharmaceutics
Subjects:
mesenchymal stem cells
bone regeneration
LNA-ASO
GapmeR
<i>Sfrp1</i>
osteogenesis
Online Access:https://www.mdpi.com/1999-4923/13/8/1277

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