Using approximate Bayesian computation to quantify cell–cell adhesion parameters in a cell migratory process

Using approximate Bayesian computation to quantify cell–cell adhesion parameters in a cell migratory process

Math heals: Using computational methods to improve design of wound healing assay Cell motility is a central process in wound healing and relies on complex cell-cell interactions. A team of mathematicians led by Ruth Baker and Kit Yates at the University of Oxford utilised computer simulations to re-...

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Main Authors: Robert J. H. Ross, R. E. Baker, Andrew Parker, M. J. Ford, R. L. Mort, C. A. Yates
Format: Article
Language:English
Published: Nature Publishing Group 2017-03-01
Series:npj Systems Biology and Applications
Online Access:https://doi.org/10.1038/s41540-017-0010-7
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spelling doaj-8a660ffbc4ef4cdea764d20b19e6fd5d2020-12-08T13:46:45ZengNature Publishing Groupnpj Systems Biology and Applications2056-71892017-03-013111010.1038/s41540-017-0010-7Using approximate Bayesian computation to quantify cell–cell adhesion parameters in a cell migratory processRobert J. H. Ross0R. E. Baker1Andrew Parker2M. J. Ford3R. L. Mort4C. A. Yates5Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Radcliffe Observatory QuarterWolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Radcliffe Observatory QuarterWolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Radcliffe Observatory QuarterMRC Human Genetics Unit, MRC IGMM, Western General Hospital, University of EdinburghDivision of Biomedical and Life Sciences, Faculty of Health and Medicine, Furness Building, Lancaster UniversityDepartment of Mathematical Sciences, Centre for Mathematical Biology, University of BathMath heals: Using computational methods to improve design of wound healing assay Cell motility is a central process in wound healing and relies on complex cell-cell interactions. A team of mathematicians led by Ruth Baker and Kit Yates at the University of Oxford utilised computer simulations to re-design wound-healing assays that efficiently identify cell motility parameters. New experimental designs through computer simulation can more accurately identify cell motility parameters by expanding the size of the domain upon which the experiment is performed, as opposed to increasing the number of experimental replicates. The results describe time and cost-saving alterations for an experimental method for evaluate complex cell-cell interactions.https://doi.org/10.1038/s41540-017-0010-7
collection DOAJ
language English
format Article
sources DOAJ
author Robert J. H. Ross
R. E. Baker
Andrew Parker
M. J. Ford
R. L. Mort
C. A. Yates
spellingShingle Robert J. H. Ross
R. E. Baker
Andrew Parker
M. J. Ford
R. L. Mort
C. A. Yates
Using approximate Bayesian computation to quantify cell–cell adhesion parameters in a cell migratory process
npj Systems Biology and Applications
author_facet Robert J. H. Ross
R. E. Baker
Andrew Parker
M. J. Ford
R. L. Mort
C. A. Yates
author_sort Robert J. H. Ross
title Using approximate Bayesian computation to quantify cell–cell adhesion parameters in a cell migratory process
title_short Using approximate Bayesian computation to quantify cell–cell adhesion parameters in a cell migratory process
title_full Using approximate Bayesian computation to quantify cell–cell adhesion parameters in a cell migratory process
title_fullStr Using approximate Bayesian computation to quantify cell–cell adhesion parameters in a cell migratory process
title_full_unstemmed Using approximate Bayesian computation to quantify cell–cell adhesion parameters in a cell migratory process
title_sort using approximate bayesian computation to quantify cell–cell adhesion parameters in a cell migratory process
publisher Nature Publishing Group
series npj Systems Biology and Applications
issn 2056-7189
publishDate 2017-03-01
description Math heals: Using computational methods to improve design of wound healing assay Cell motility is a central process in wound healing and relies on complex cell-cell interactions. A team of mathematicians led by Ruth Baker and Kit Yates at the University of Oxford utilised computer simulations to re-design wound-healing assays that efficiently identify cell motility parameters. New experimental designs through computer simulation can more accurately identify cell motility parameters by expanding the size of the domain upon which the experiment is performed, as opposed to increasing the number of experimental replicates. The results describe time and cost-saving alterations for an experimental method for evaluate complex cell-cell interactions.
url https://doi.org/10.1038/s41540-017-0010-7
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