Cell Fate Decision as High-Dimensional Critical State Transition.

Cell Fate Decision as High-Dimensional Critical State Transition.

Cell fate choice and commitment of multipotent progenitor cells to a differentiated lineage requires broad changes of their gene expression profile. But how progenitor cells overcome the stability of their gene expression configuration (attractor) to exit the attractor in one direction remains elusi...

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Bibliographic Details
Main Authors: Mitra Mojtahedi, Alexander Skupin, Joseph Zhou, Ivan G Castaño, Rebecca Y Y Leong-Quong, Hannah Chang, Kalliopi Trachana, Alessandro Giuliani, Sui Huang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-12-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC5189937?pdf=render

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