Dietary ω-3 Polyunsaturated Fatty Acid DHA: A Potential Adjuvant in the Treatment of Cancer

Dietary ω-3 Polyunsaturated Fatty Acid DHA: A Potential Adjuvant in the Treatment of Cancer

ω-3 Polyunsaturated fatty acids (PUFAs), mainly present in fish oil, are part of the human diet. Among PUFAs, docosahexaenoic acid (DHA) has received particular attention for its anti-inflammatory, antiproliferative, proapoptotic, antiangiogenetic, anti-invasion, and antimetastatic properties. These...

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Main Authors: Nicolò Merendino, Lara Costantini, Laura Manzi, Romina Molinari, Donatella D'Eliseo, Francesca Velotti
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2013/310186
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spelling doaj-8a57957bbe6c49d1a12f60fb35f3249f2020-11-24T21:02:56ZengHindawi LimitedBioMed Research International2314-61332314-61412013-01-01201310.1155/2013/310186310186Dietary ω-3 Polyunsaturated Fatty Acid DHA: A Potential Adjuvant in the Treatment of CancerNicolò Merendino0Lara Costantini1Laura Manzi2Romina Molinari3Donatella D'Eliseo4Francesca Velotti5Tuscia University, Department of Ecological and Biological Sciences (DEB), Largo dell’Università, 01100 Viterbo, ItalyTuscia University, Department of Ecological and Biological Sciences (DEB), Largo dell’Università, 01100 Viterbo, ItalyTuscia University, Department of Ecological and Biological Sciences (DEB), Largo dell’Università, 01100 Viterbo, ItalyTuscia University, Department of Ecological and Biological Sciences (DEB), Largo dell’Università, 01100 Viterbo, ItalyTuscia University, Department of Ecological and Biological Sciences (DEB), Largo dell’Università, 01100 Viterbo, ItalyTuscia University, Department of Ecological and Biological Sciences (DEB), Largo dell’Università, 01100 Viterbo, Italyω-3 Polyunsaturated fatty acids (PUFAs), mainly present in fish oil, are part of the human diet. Among PUFAs, docosahexaenoic acid (DHA) has received particular attention for its anti-inflammatory, antiproliferative, proapoptotic, antiangiogenetic, anti-invasion, and antimetastatic properties. These data suggest that DHA can exert antitumor activity potentially representing an effective adjuvant in cancer chemotherapy. This review is focused on current knowledge supporting the potential use of DHA for the enhancement of the efficacy of anticancer treatments in relation to its ability to enhance the uptake of anticancer drugs, regulate the oxidative status of tumor cells, and inhibit tumor cell invasion and metastasis.http://dx.doi.org/10.1155/2013/310186
collection DOAJ
language English
format Article
sources DOAJ
author Nicolò Merendino
Lara Costantini
Laura Manzi
Romina Molinari
Donatella D'Eliseo
Francesca Velotti
spellingShingle Nicolò Merendino
Lara Costantini
Laura Manzi
Romina Molinari
Donatella D'Eliseo
Francesca Velotti
Dietary ω-3 Polyunsaturated Fatty Acid DHA: A Potential Adjuvant in the Treatment of Cancer
BioMed Research International
author_facet Nicolò Merendino
Lara Costantini
Laura Manzi
Romina Molinari
Donatella D'Eliseo
Francesca Velotti
author_sort Nicolò Merendino
title Dietary ω-3 Polyunsaturated Fatty Acid DHA: A Potential Adjuvant in the Treatment of Cancer
title_short Dietary ω-3 Polyunsaturated Fatty Acid DHA: A Potential Adjuvant in the Treatment of Cancer
title_full Dietary ω-3 Polyunsaturated Fatty Acid DHA: A Potential Adjuvant in the Treatment of Cancer
title_fullStr Dietary ω-3 Polyunsaturated Fatty Acid DHA: A Potential Adjuvant in the Treatment of Cancer
title_full_unstemmed Dietary ω-3 Polyunsaturated Fatty Acid DHA: A Potential Adjuvant in the Treatment of Cancer
title_sort dietary ω-3 polyunsaturated fatty acid dha: a potential adjuvant in the treatment of cancer
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2013-01-01
description ω-3 Polyunsaturated fatty acids (PUFAs), mainly present in fish oil, are part of the human diet. Among PUFAs, docosahexaenoic acid (DHA) has received particular attention for its anti-inflammatory, antiproliferative, proapoptotic, antiangiogenetic, anti-invasion, and antimetastatic properties. These data suggest that DHA can exert antitumor activity potentially representing an effective adjuvant in cancer chemotherapy. This review is focused on current knowledge supporting the potential use of DHA for the enhancement of the efficacy of anticancer treatments in relation to its ability to enhance the uptake of anticancer drugs, regulate the oxidative status of tumor cells, and inhibit tumor cell invasion and metastasis.
url http://dx.doi.org/10.1155/2013/310186
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AT rominamolinari dietaryō3polyunsaturatedfattyaciddhaapotentialadjuvantinthetreatmentofcancer
AT donatelladeliseo dietaryō3polyunsaturatedfattyaciddhaapotentialadjuvantinthetreatmentofcancer
AT francescavelotti dietaryō3polyunsaturatedfattyaciddhaapotentialadjuvantinthetreatmentofcancer
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