CAR T-Cells Targeting the Integrin αvβ6 and Co-Expressing the Chemokine Receptor CXCR2 Demonstrate Enhanced Homing and Efficacy against Several Solid Malignancies

CAR T-Cells Targeting the Integrin αvβ6 and Co-Expressing the Chemokine Receptor CXCR2 Demonstrate Enhanced Homing and Efficacy against Several Solid Malignancies

Despite the unprecedented clinical success of chimeric antigen receptors (CAR) T-cells against haematological malignancy, solid tumors impose a far greater challenge to success. Largely, this stems from an inadequate capacity of CAR T-cells that can traffic and maintain function within a hostile mic...

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Bibliographic Details
Main Authors: Lynsey M. Whilding, Leena Halim, Benjamin Draper, Ana C. Parente-Pereira, Tomasz Zabinski, David Marc Davies, John Maher
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Cancers
Subjects:
CAR-T
immunotherapy
αvβ6
integrin
homing
chemokine receptor
solid tumor
cancer
chimeric antigen receptor
T-cell
Online Access:https://www.mdpi.com/2072-6694/11/5/674

Internet

https://www.mdpi.com/2072-6694/11/5/674

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